High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML
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- 作者：Yue Zhao1 ; Qi Liu2 ; 3 ; Pankaj Acharya1 ; Kristy R. Stengel1 ; Quanhu Sheng2 ; Xiaofan Zhou4 ; Hojoong Kwak5 ; Melissa A. Fischer6 ; James E. Bradner7 ; Stephen A. Strickland6 ; 8 ; Sanjay R. Mohan6 ; 8 ; Michael R. Savona6 ; 8 ; Bryan J. Venters9 ; Ming-Ming Zhou10 ; John T. Lis5 ; Scott W. Hiebert1 ; 8 ; scott.hiebert@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：16
- 期：7
- 页码：2003-2016
- 全文大小：4404 K
文摘
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BET inhibitors impair the release of promoter-proximal paused RNA polymerases
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BET inhibitors repress KIT transcription through its downstream enhancer
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BET inhibitors repress MCL1-targeting microRNAs MIR29C and MIR29B2
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Inhibition of MCL1 triggers cell death in BET-inhibitor-treated AML cells