K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping
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- 作者：Ulas Tenekeci1 ; 4 ; Michael Poppe1 ; 4 ; Knut Beuerlein1 ; 4 ; Christin Buro1 ; 4 ; Helmut Mü ; ller1 ; Hendrik Weiser1 ; Daniela Kettner-Buhrow1 ; Katharina Porada1 ; Doris Newel1 ; Ming Xu2 ; Zhijian J. Chen2 ; Julia Busch3 ; M. Lienhard Schmitz3 ; Michael Kracht1 ; michael.kracht@pharma.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ubiquitin ; K63R ubiquitin ; DCP1a ; TRAF6 ; P-body ; IL-1
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：62
- 期：6
- 页码：943-957
- 全文大小：4765 K
文摘
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K63-linked ubiquitin regulates DCP1a phosphorylation, P-body assembly, and mRNA decay
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DCP1a is ubiquitylated and binds to TRAF6 and to ubiquitin binding domains
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TRAF6 regulates decapping factors and mRNA decay at multiple levels
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DCP1a C-terminal lysines participate in decapping activity and P-body remodeling