Needleless coaxial electrospinning: A novel approach to mass production of coaxial nanofibers

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• 作者：Lucie Vysloužilov&aacute ; ^a ; ¹ ; Matej Buzgo^b ; ^c ; ^d ; ¹ ; ^{buzgo@labdemo.cz} ; Pavel Pokorný ; ^a ; Jiří ; Chvojka^a ; Andrea Mí ; čkov&aacute ; ^b ; ^c ; ^d ; Michala Rampichov&aacute ; ^b ; ^c ; ^d ; Jiří ; Kula^e ; Karel Pejchar^f ; Martin Bí ; lek^f ; David Luk&aacute ; &scaron ; ^a ; Evžen Amler^b ; ^c ; ^d
• 关键词：Core-shell nanofibers ; Coaxial electrospinning ; Needleless electrospinning ; Fluorescent spectroscopy
• 刊名：International Journal of Pharmaceutics
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：516
• 期：1-2
• 页码：293-300
• 全文大小：2312 K
• 卷排序：516

文摘

Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering.