Controlled Attenuation Parameter (CAP): A Novel VCTE™ Guided Ultrasonic Attenuation Measurement for the Evaluation of Hepatic Steatosis: Preliminary Study and Validation in a Cohort of Patients with Chronic Liver Disease from Various Causes

详细信息    查看全文

• 作者：Magali Sasso ; Michel Beaugr ; Victor de Ledinghen ; Catherine Douvin ; Patrick Marcellin ; Raoul Poupon ; Laurent S ; rin ; Vé ; ronique Miette
• 关键词：Ultrasound attenuation ; Attenuation ; Liver ; Steatosis ; Steato-hepatitis ; Nonalcoholic fatty liver disease ; Elastography ; Vibration controlled transient elastography ; VCTE™ ; Fibroscan^® ;
• 刊名：Ultrasound in Medicine and Biology
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：36
• 期：11
• 页码：1825-1835
• 全文大小：681 K

文摘

There is a need for noninvasive methods to detect liver steatosis, which can be a factor of liver fibrosis progression. This work aims to evaluate a novel ultrasonic controlled attenuation parameter (CAP) devised to target, specifically, liver steatosis using a sophisticated process based on vibration control transient elastography (VCTE™). CAP was first validated as an estimate of ultrasonic attenuation at 3.5 MHz using Field II simulations and tissue-mimicking phantoms. Performance of the CAP was then appraised on 115 patients, taking the histological grade of steatosis as reference. CAP was significantly correlated to steatosis (Spearman ρ = 0.81, p < 10⁻¹⁶). Area under receiver operative characteristic (ROC) curve (AUC) was equal to 0.91 and 0.95 for the detection of more than 10 % and 33 % of steatosis, respectively. Furthermore, results show that CAP can efficiently separate several steatosis grades. These promising results suggest that CAP is a noninvasive, immediate, objective and efficient method to detect and quantify steatosis. (E-mail: magali.sasso@echosens.com)