On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets

详细信息    查看全文

• 作者：Nikita Reznikp>&lowast ; p>p> ; p>p>reznik@ohsu.edu" class="auth_mailp> ; Guillaume Lajoiniep>&dagger ; p> ; Oleksandr Shpakp>&dagger ; p> ; Erik C. Gelderblomp>&dagger ; p> ; Ross Williamsp>&Dagger ; p> ; Nico de Jongp>§ ; p> ; Michel Versluisp>&dagger ; p> ; Peter N. Burnsp>&lowast ; p>p> ; p>p>&Dagger ; p>
• 关键词：Ultrasound contrast agents ; Perfluorocarbon droplets ; Droplet vaporization ; High-speed imaging ; Microbubble characterization
• 刊名：Ultrasound in Medicine and Biology
• 出版年：June 2014
• 年：2014
• 卷：40
• 期：6
• 页码：1379-1384
• 全文大小：522 K

文摘

The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice.