Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
详细信息 查看全文
- 作者：Kelly L. Warfielda ; 1 ; warfieldk@ebsi.com" class="auth_mail" title="E-mail the corresponding author ; Emily M. Plummerb ; 1 ; Emily.plummer@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Andrew C. Saycec ; 1 ; andrew.sayce@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Dominic S. Alonzic ; dominic.alonzi@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; William Tangb ; wtang@lji.org" class="auth_mail" title="E-mail the corresponding author ; Beatrice E. Tyrrellc ; beatrice.tyrrell@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Michelle L. Hillc ; michelle.hill@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Alessandro T. Caputoc ; alessandro.caputo@stx.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Sarah S. Killingbeckd ; sskillingbeck@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author ; P. Robert Beattyd ; prbeatty@berkeley.edu" class="auth_mail" title="E-mail the corresponding author ; Eva Harrisd ; eharris@berkeley.edu" class="auth_mail" title="E-mail the corresponding author ; Ren Iwakie ; r-iwaki@fujichemical.co.jp" class="auth_mail" title="E-mail the corresponding author ; Kyoko Kinamie ; s1160215@ems.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Daisuke Idee ; s1260204@ems.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author ; J.L. Kiappesc ; john.kiappes@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Atsushi Katoe ; kato@med.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Michael D. Buckb ; mdsbuck@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kevin Kingb ; kevindalesamuelking@gmail.com" class="auth_mail" title="E-mail the corresponding author ; William Eddyb ; william.e.eddy@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mansoora Khaliqa ; khlaliqm@ebsi.com" class="auth_mail" title="E-mail the corresponding author ; Aruna Sampatha ; sampatha1@ebsi.com" class="auth_mail" title="E-mail the corresponding author ; Anthony M. Trestona ; trestona@ebsi.com" class="auth_mail" title="E-mail the corresponding author ; Raymond A. Dwekc ; raymond.dwek@exeter.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Sven G. Enterleinf ; sven@integratedbiotherapeutics.com" class="auth_mail" title="E-mail the corresponding author ; Joanna L. Millerc ; joanna.miller@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Nicole Zitzmannc ; nicole.zitzmann@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Urban Ramstedtg ; urban_ramstedt@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Sujan Shrestab ; sujan@lji.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Iminosugar ; UV-4B ; Dengue ; Antibody-dependent enhancement ; Antiviral ; Glucosidase
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：93-98
- 全文大小：1014 K
文摘
- •
The iminosugar UV-4B has in vitro activity against all 4 dengue virus serotypes.
- •
Inhibition of ER α-glucosidases is responsible for UV-4B activity against dengue.
- •
In vivo efficacy studies inform clinical trial design for UV-4B treatment of dengue.