Independent Correlation of Serum Homocysteine with Cerebral Microbleeds in Patients with Acute Ischemic Stroke due to Large-Artery Atherosclerosis

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• 作者：Bian-Rong Wang ; MD^* ; ¹ ; Zhou Ou ; MD^&dagger ; ; ¹ ; Teng Jiang ; MD^&dagger ; ; Ying-Dong Zhang ; MD^&dagger ; ; Hong-Dong Zhao ; MD^&dagger ; ; You-Yong Tian ; MD^&dagger ; ; Jian-Quan Shi ; MD^&dagger ; ; ^{myxiyi_0717@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jun-Shan Zhou ; MD^&dagger ; ; ^{zhjsh333@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Acute ischemic stroke ; large-artery atherosclerosis ; cerebral microbleeds ; homocysteine ; age
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：25
• 期：11
• 页码：2746-2751
• 全文大小：482 K

文摘

The severity of cerebral microbleeds (CMBs) affected the prognosis of patients with acute cerebrovascular disease. Considering the impact of CMBs on clinical decision, it is necessary to assess the risk factors of CMBs. We aimed to evaluate the independent risk factors of CMBs in patients with acute ischemic stroke of large-artery atherosclerosis.

Materials and Methods

112 patients were enrolled in the study. The baseline information, the results of laboratory examination and cranial MRI were collected. The independent risk factors of CMBs in patients with acute ischemic stroke due to large-artery atherosclerosis were evaluated.

Results

CMBs were found in 56 (50%) patients. Older age and higher homocysteine (Hcy) level were associated with an elevated chance of occurrence of CMBs. Further, there was a positive correlation between CMBs grade and serum Hcy level.

Conclusions

Serum Hcy level is strongly associated with the presence of CMBs in patients with acute ischemic stroke due to large-artery atherosclerosis. Serum Hcy level may be a potential therapeutic target for alleviating adverse clinical outcomes of CMBs.