Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells

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• 作者：Antonino Martines^a ; ¹ ; Roberto Stifanese^b ; ¹ ; Emanuela L. Faelli^c ; Luisa Perasso^c ; Ilaria Melloni^d ; Piero Ruggeri^c ; Monica Averna^a ; ^{monica.averna@unige.it}
• 关键词：Ca2+-dependent proteolysis ; Calpain ; eNOS ; nNOS ; HSP90 ; Diabetes
• 刊名：Biochimie
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：20-27
• 全文大小：1213 K
• 卷排序：133

文摘

In endothelial caveolin-1 microdomain calpain-1 is associated with eNOS and HSP90. Rise in [Ca2+]i induces digestion of eNOS and recruitment of HSP90 in microdomain. Cells with a reorganized microdomain are more resistant to Ca2+ induced cell death. In aorta of diabetic rats both eNOS and HSP90 are digested. Depletion of HSP90 triggers the transition of calpain function to pathology.