Interferometric detection of microRNAs using a capillary optofluidic sensor

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• 关键词：Opticfluidics ; Microfluidics ; Optical microfibers ; Photonic biosensors ; MicroRNA detection
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：999-1006
• 全文大小：2420 K
• 卷排序：242

文摘

An optofluidic sensor by assembling a microfiber in lateral contact with a silica capillary in the same direction has been demonstrated for the first time. The fabrication and characteristics of the optofluidic sensor has been described and it shows a lot of advantages such as high refractive index sensitivity, high resistance to environmental perturbations, improved portability, easy fabrication and handling, and intrinsic connection to fiber-optic measurement. Its optic principle for biomolecular binding at the capillary interior has been analyzed detailedly. Its application for microRNA detection has been demonstrated.