Preparation and characterization of sodium alginate/chitosan microparticles containing esculin
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- 作者：Marta Tsirigotis-Maniecka ; marta.tsirigotis@pwr.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Roman Gancarz ; Kazimiera A. Wilk
- 关键词：Microencapsulation ; Esculin-loaded microparticles ; Microhydrogels ; Stability studies ; pH-dependent release
- 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
- 出版年：2016
- 出版时间：5 December 2016
- 年：2016
- 卷：510
- 期：Complete
- 页码：22-32
- 全文大小：2045 K
文摘
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Naturally occurring esculin (ESC) was successfully encapsulated in sodium alginate/chitosan hydrogel matrix.
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The final microparticles (ACPs) were fabricated with both external, and internal gelation methods.
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ACPs were described with regard to structure, size and morphology, swelling and release kinetics.
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ACPs protected ESC in the simulated upper gastrointestinal tract, and enabled its release in the simulated intestinal fluid.