Application of microparticle-enhanced cultivation to increase the access of oxygen to Aspergillus terreus ATCC 20542 mycelium and intensify lovastatin biosynthesis in batch and continuous fed-batch stirred tank bioreactors
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- 作者：Joanna Gonciarz ; Anna Kowalska ; Marcin Bizukojc ; marcin.bizukojc@p.lodz.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aeration ; Bioreactors ; Control ; Filamentous fungi ; Lovastatin ; Microparticle-enhanced cultivation
- 刊名：Biochemical Engineering Journal
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：178-188
- 全文大小：3178 K
文摘
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Oxygen is crucial for lovastatin biosynthesis by Aspergillus terreus.
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In macroscopic pellets insufficient amount of oxygen is transferred to the cells.
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Due to talc microparticles microscopic pellets are formed in the bioreactor.
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Optimum talc concentration for lovastatin formation in the batch bioreactor exists.
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Microparticles enhance lovastatin formation the most in the fed-batch bioreactor.