Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
详细信息 查看全文
- 作者：Bryan B. Bridgemana ; 1 ; Pu Wangb ; 1 ; Boping Yeb ; Jill C. Pellinga ; d ; 2 ; Olga V. Volpertc ; d ; olgavolp@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Xin Tonga ; d ; x-tong1@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：UVB ; ultraviolet B ; mTOR ; mammalian target of rapamycin ; AMPK ; AMP-activated protein kinase ; NMSC ; non-melanoma skin cancer ; SCC ; squamous cell carcinomas ; p70S6K ; ribosomal protein S6 kinase ; 4E-BP1 ; eukaryotic initiation factor 4E binding protein ; CDK2 ; cyclin-dependent kinase 2 ; LC3 ; microtubule-associated protein 1A/1B-light chain 3 ; PI3K ; phosphoinositide 3-kinase
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：28
- 期：5
- 页码：460-468
- 全文大小：2626 K
文摘
- •
UVB irradiation activates mTOR, a critical player in skin carcinogenesis.
- •
Activation of mTOR by UVB is dependent on PI3K/Akt signaling.
- •
Apigenin inhibits UVB-induced mTOR signaling through activation of AMPK.
- •
mTOR inhibition by apigenin enhances autophagy, further reducing proliferation in keratinocytes.