Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics
详细信息 查看全文
- 作者：Hongwei Jina ; 1 ; Xiao Chengb ; 1 ; Yihua Peic ; 1 ; Jianguo Fud ; Zhi Lyub ; Huifang Penge ; Qin Yaoc ; Yu Jiangf ; biozone@163.com" class="auth_mail" title="E-mail the corresponding author ; Lianzhong Luog ; lzluo@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Huiqin Zhuoc ; zhuohuiqin@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microvascular endothelial cells ; Lung cancer ; Hspd1 ; Tagln2 ; Biomarkers
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：16 March 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：77-88
- 全文大小：2030 K
文摘
- •
> 98% pure mouse normal, tumor-derived CD105+ TECs were isolated from 0.5 cm tumors.
- •
Hspd1, Tagln2 primary upregulators in TECs proteomics, immunohistochemistry
- •
Significantly higher Hspd1 and lower Tagln2 levels were detected in LC patient sera.
- •
High Tagln2 linked with tumor dev., lymph node metastasis, neural invasion in LC