Interplay between Protein Thermal Flexibility and Kinetic Stability

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• 作者：Andrea G. Quezada¹ ; A. Jessica Dí ; az-Salazar¹ ; Nallely Cabrera² ; Ruy Pé ; rez-Montfort² ; Á ; ngel Pi&ntilde ; eiro³ ; ^{angel.pineiro@usc.es} ; Miguel Costas¹ ; ⁴ ; ^{costasmi@unam.mx}
• 关键词：kinetic stability ; protein flexibility ; activation energy ; unfolding MD ; unfolding cooperativity ; DSC ; calorimetry ; triosephosphate isomerase ; TIM barrel ; chimeras
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：167-179
• 全文大小：3230 K
• 卷排序：25

文摘

Kinetic stability and unfolding cooperativity are linked to thermal flexibility Thermal flexibility is given by residue displacements due to a temperature gradient There are concerted effects among residues within a certain global spatial context Protein kinetic stability can be enhanced modifying its thermal flexibility