Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power

详细信息    查看全文

• 作者：Isabel C.F.R. Ferreira ; Maria-Joã ; o R.P. Queiroz ; Miguel Vilas-Boas ; Letı ; ́ ; cia M. Estevinho ; Agathe Begouin and Gilbert Kirsch
• 关键词：Diarylamines ; Benzothiophenes ; Antioxidant activity ; Structure– ; activity relationships
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：1 March 2006
• 年：2006
• 卷：16
• 期：5
• 页码：1384-1387
• 全文大小：109 K

文摘

The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and BHA and BHT for the second. For both methods it was possible to establish some structure–activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO₂Et, CO₂H).