- 作者：Catherine L. Granger ; Christine F. McDonald ; Louis Irving ; Ross A. Clark ; Karla Gough ; Andrew Murnane ; Linda Mileshkin ; Meinir Krishnasamy ; Linda Denehy
- 关键词：Lung cancer ; Physical activity ; Accelerometery ; Functional decline ; Health-related quality of life
- 刊名：Lung Cancer
- 出版年：February, 2014
- 年：2014
- 卷：83
- 期：2
- 页码：292-299
- 全文大小：1459 K
Objectives
Physical activity has been infrequently measured objectively in non-small cell lung cancer (NSCLC). We aimed to investigate levels of physical activity, functional and patient reported outcomes at diagnosis and over six months in participants with recently diagnosed NSCLC and compare results with both physical activity guidelines and outcomes of similar-aged healthy individuals.Methods
This prospective observational study assessed 50 individuals from three Australian tertiary hospitals with stage I-IIIB NSCLC at diagnosis, then 10 weeks and six months later. Thirty five healthy individuals without cancer were assessed once. Outcome measures included tri-axial accelerometery (number of steps per day), six minute walk distance (6MWD), muscle strength and questionnaires including health-related quality of life (HRQoL).
Results
Individuals with NSCLC were engaged in significantly less physical activity than similar-aged healthy individuals, with 60% not meeting physical activity guidelines. At diagnosis they had worse quadriceps strength, nutritional status and HRQoL. Over six months, participants with NSCLC experienced decline in self-reported physical activity, 6MWD and muscle strength, and worsening symptoms.
Conclusion
At diagnosis individuals with NSCLC engage in less physical activity, are weaker and more depressed than healthy individuals and their self-reported physical activity declines over six months. Future studies are required to investigate the efficacy of interventions to increase physical activity.