Developmental Toxicity and Potential Teratogenicity of Compound Danshen Tablet, Angong Niuhuang Pill, and Lidan Paishi Tablet in Zebrafish Embryos

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• 作者：Jie-feng Chen^a ; Tong Liu^a ; Dan-ping Huang^b ; Qi-di He^a ; Zuan-guang Chen^a ; Mei-cun Yao^a ; ^{yaomeicun@gmail.com}
• 关键词：Chinese patent medicines ; developmental toxicity ; drug safety ; potential teratogenicity ; zebrafish embryos
• 刊名：Chinese Herbal Medicines
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：9
• 期：1
• 页码：74-79
• 全文大小：994 K
• 卷排序：9

文摘

Herbal medicines containing toxic herbs or minerals such as Compound Danshen Tablet (CDT), Angong Niuhuang Pill (ANP), and Lidan Paishi Tablet (LPT) are avoided or used with caution for pregnant women because of potential teratogenicity. To understand their mechanism, they were chosen as model subjects for the research.MethodsZebrafish embryos were used to evaluate their potential teratogenic risk in vitro.ResultsAll of them showed teratogenic and lethal effects in zebrafish embryos, with the EC50 values at 351, 793, and 220 μg/mL, and LC50 values at 417, 596, and 380 μg/mL, respectively. CDT and LPT, displaying week potential teratogenicity as their teratogenicity indexes were greater than 1, induced tail malformation and cardiac edema mainly in zebrafish embryos, respectively.ConclusionThe results provide the significant guidance of clinical safety of medication.