Altered axonal excitability properties and nerve edema in POEMS syndrome
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- 作者：Satsuki Mitsuma ; Sonoko Misawa ; Kazumoto Shibuya ; Sagiri Isose ; Yukari Sekiguchi ; Yuta Iwai ; Minako Beppu ; Keisuke Watanabe ; Hiroshi Amino ; Satoshi Kuwabara ; kuwabara-s@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：POEMS syndrome ; Axonal excitability ; Nerve ultrasound ; Ion channel
- 刊名：Clinical Neurophysiology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：126
- 期：10
- 页码：2014-2018
- 全文大小：504 K
文摘
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Axonal excitability and its correlation with serum VEGF and nerve edema detected by ultrasound were studied in POEMS syndrome.
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Excitability testing suggested possibly altered sodium, potassium, and inward rectifying currents, some of which were correlated with VEGF levels and nerve edema.
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In addition to structural changes (demyelination), nerve edema induced by upregulated VEGF, and upregulated inflammatory cytokines can modulate profiles of POEMS neuropathy.