Neonatal isoflavone exposure interferes with the reproductive system of female Wistar rats
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- 作者：Dennis R. Mü ; llera ; Sebastian T. Soukupb ; Anne Kurrata ; Xin Liuc ; Marion Schmicked ; Ming-Yong Xiec ; Sabine E. Kullingb ; Patrick Diela ; diel@dshs-koeln.de" class="auth_mail" title="E-mail the corresponding author (Prof.)
- 关键词：bw ; body weight ; DAI ; daidzein ; FSH ; follicle-stimulating hormone ; GEN ; genistein ; GLY ; glycitein ; GnRH ; gonadotropin-releasing hormone ; HPG ; hypothalamic-pituitary-gonadal ; IDD ; isoflavone depleted diet ; IRD ; isoflavone rich diet ; ISO ; isoflavones ; LH ; luteinizing hormone ; LOD ; limit of detection ; LOQ ; limit of quantification ; NTP ; National Toxicology Program ; PND ; postnatal day ; SBIF ; soy based infant formula ; Sult ; sulfotransferases ; T4 ; thyroxin ; UWW ; uterine wet weight ; VO ; vaginal opening
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：16 November 2016
- 年：2016
- 卷：262
- 期：Complete
- 页码：39-48
- 全文大小：1416 K
文摘
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Rats were fed with a soy based isoflavone extract during neonatal period.
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Neonatal direct isoflavone exposure resulted in estrogenic effect in rats.
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Neonatal isoflavone exposure resulted in more irregular estrus cycles later in life.