Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility
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- 作者：Rosemary C. Bagot1 ; Hannah M. Cates1 ; Immanuel Purushothaman1 ; Zachary S. Lorsch1 ; Deena M. Walker1 ; Junshi Wang2 ; Xiaojie Huang2 ; Oliver M. Schlü ; ter2 ; Ian Maze1 ; Catherine J. Peñ ; a1 ; Elizabeth A. Heller1 ; 3 ; Orna Issler1 ; Minghui Wang4 ; Won-min Song4 ; Jason. L. Stein5 ; 6 ; Xiaochuan Liu1 ; Marie A. Doyle1 ; Kimberly N. Scobie1 ; Hao Sheng Sun1 ; Rachael L. Neve7 ; Daniel Geschwind6 ; Yan Dong2 ; Li Shen1 ; li.shen@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Bin Zhang4 ; bin.zhang@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Eric J. Nestler1 ; eric.nestler@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：90
- 期：5
- 页码：969-983
- 全文大小：4254 K
文摘
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A large-scale multi-brain region transcriptomic cohort to probe stress susceptibility
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Reveals susceptible and resilient transcriptional networks across brain regions
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Identifies many novel hub genes that emerge in susceptible mice
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In vivo validation of key regulators at molecular, synaptic, and behavioral levels