Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity
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- 作者：Shuo Yua ; 1 ; Tianpeng Dub ; 1 ; Zhuguo Liua ; Qiaoling Wua ; Guixue Fenga ; Mingxin Donga ; Xiaowei Zhoua ; Ling Jiangb ; lingjiang@wipm.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Qiuyun Daia ; qy_dai@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Conopeptide ; Im10A ; Isolation ; Synthesis ; NMR structure ; Analgesic activity
- 刊名：Peptides
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：15-20
- 全文大小：1270 K
文摘
- •
A novel conopeptide with 11 residues was isolated and synthesized.
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Only two and one residues were allocated at loop1 and loop2 of “CC
CC”, respectively.- •
Im10A showed a ribbon structure with disulfide connectivity “I–IV, II–III”.
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Im10A exhibited moderate analgesic activity.
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The new motif was useful for the future development of biomimetic compounds.