Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness
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- 作者：Nicholas D. Lanta ; Laura E. Gonzalez-Laraa ; Adrian M. Owena ; Davinia Ferná ; ndez-Espejoa ; b ;
- 关键词：Disorders of consciousness ; Default mode network ; Thalamus ; Basal ganglia ; Anterior forebrain mesocircuit ; Precuneus ; DTI ; Tractography ; White matter ; Traumatic brain injury ; Hypoxic&ndash ; ischemic brain injury ; Vegetative state ; Minimally conscious state
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：10
- 期：Complete
- 页码：27-35
- 全文大小：911 K
文摘
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We assess the integrity of the fibers connecting the anterior forebrain mesocircuit and the default mode network in DOC.
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DOC patients have significantly lower FA in subcortico-cortical and cortico-cortical fiber tracts relative to controls.
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The damage in these tracts is more severe in vegetative state patients than those who are at least minimally conscious.
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Individual tract analysis revealed significant damage in all tracts connecting to the precuneus in DOC patients.