PTP4A3 is a target for inhibition of cell proliferatin, migration and invasion through Akt/mTOR signaling pathway in glioblastoma under the regulation of miR-137
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- 作者：Liling Wanga ; Jianxun Liua ; Zhiqiang Zhonga ; Xuhai Gonga ; Wei Liub ; Lei Shic ; Xuesong Lia ; 13329391666@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-137 ; PTP4A3 ; Akt ; mTOR ; Glioblastoma multiforme
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：441-450
- 全文大小：4531 K
文摘
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PTP4A3 is upregulated in GBM.
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Knockdown of PTP4A3 inhibits GBM cell proliferation, migration and invasion.
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PTP4A3 regulates the Akt/mTOR signaling pathway.
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PTP4A3 is a direct target of miR-137.
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MiR-137 regulates GBM cell malignancy partially through PTP4A3-mediated Akt/mTOR signaling pathway.