Evaluation of adherence to a triple antiretroviral therapy in HIV-positive patients
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文摘
The purpose of the study is to know the adherence to a triple antiretroviral therapy, to analyse the treatment attachment associated factors and to evaluate the impact on therapeutic response related to adherence. Adherence degree was estimated by direct questionnaire. The CD4+ cells counts and viral load were made before initiating treatment and also 4 months after it. The impact of introducing a protocolized informing system for each patient about the treatment is analysed also. We studied 164 patients. Differences within adherence degree depending on age or sex were not found. Adherence rates were worse in IDU patients. We did not find differences on adherence related to nucleoside analogues, but patients on a bid regimen were found to have better adherence than those in the group receiving a tid regimen. Patients who received protocolized information presented a non significant trend to have better adherence. Adherence to therapy is related to higher CD4+ cells increases at the fourth month and a greater viral load decrease. At least 24.4 % of patients with triple therapy do not reach a proper adherence degree; the IDU patients are the ones with lower adherence rates. Treatments administered bid have better adherence than those administrated tid. Introducing a standardized information protocol might improve adherence rates. The response to antiretroviral therapy is conditioned by adherence degree.