Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

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• 作者：Chiara Greggio¹ ; ⁶ ; Pooja Jha² ; ⁶ ; Sameer S. Kulkarni³ ; ⁶ ; Sylviane Lagarrigue¹ ; Nicholas T. Broskey¹ ; Marie Boutant³ ; Xu Wang² ; Sonia Conde Alonso¹ ; ⁴ ; Emmanuel Ofori¹ ; Johan Auwerx² ; ^{admin.auwerx@epfl.ch} ; Carles Cantó ; ³ ; ^{carlos.cantoalvarez@rd.nestle.com} ; Francesca Amati¹ ; ⁴ ; ⁵ ; ⁷ ; ^{francesca.amati@unil.ch}
• 关键词：mitochondria ; electron transport chain ; respiratory complex ; supercomplex ; endurance training ; exercise intervention ; aging ; human ; skeletal muscle ; pre-/post-design
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：301-311
• 全文大小：3083 K
• 卷排序：25

文摘

Exercise differentially modulates electron transport chain complexes in human muscle Respiratory supercomplex assemblies increase in response to exercise Free complexes shift toward functional supercomplexes after training Increases in supercomplexes are accompanied by increases in muscle respiration