LiCl regulates mitochondrial biogenesis during megakaryocyte development

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• 作者：Ram Babu Undi^a ; Usha Gutti^b ; ^{guttiusha@gmail.com} ; Ravi Kumar Gutti^a ; ^{guttiravi@gmail.com} ; ^{guttiravi@uohyd.ac.in}
• 关键词：Megakaryocyte ; Wnt signaling ; Mitochondria ; LiCl
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：193-201
• 全文大小：2444 K
• 卷排序：39

文摘

LiCl could activate wnt signaling in megakaryocytes. LiCl could induce megakaryocyte maturation markers CD41 and CD42. Increase in mitochondrial biogenesis in megakaryocytes upon induction with LiCl. Mitochondrial mediated ROS is essential for megakaryocyte development.