Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function
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- 作者：Rojin Sharifa ; Mehdi Aghsamia ; Mehdi Gharghabia ; Mehdi Sanatia ; Tina Khorshidahmada ; b ; c ; Gelareh Vakilzadeha ; Hajar Mehdizadehd ; Shervin Gholizadehe ; Ghorban Taghizadehd ; Mohammad Sharifzadeha ; msharifzadeh@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melatonin ; Protein kinase A ; Spatial memory ; Hippocampus ; Oxidative stress ; Mitochondrial function
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：115-124
- 全文大小：1484 K
文摘
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Melatonin ameliorates H89 (Protein Kinase AII Inhibitor) related memory impairment.
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Melatonin prevents H89-induced oxidative and promotes antioxidative defense system.
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Melatonin impedes H89-mediated mitochondrial dysfunction and cytochrome c release.
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Melatonin can be used for oxidative-related neurodegenerative disorders.