The role of mitochondrial DNA damage in the development of atherosclerosis
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- 作者：Emma P.K. Yu ; epky2@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Martin R. Bennett
- 关键词：AMPK ; AMP activated protein kinase ; cGAS ; cyclic GMP-AMP synthase ; DAMP ; damage-associated molecular pattern ; Drp1 ; dynamin-related protein 1 ; FGF21 ; fibroblast growth factor 21 ; IFN ; interferon ; MOMP ; mitochondrial outer membrane permeabilisation ; MPTP ; mitochondrial permeability transition pore ; mtDNA ; mitochondrial DNA ; NFκβ ; nuclear factor kappa beta ; Opa1 ; optic atrophy 1 ; PAMP ; pathogen-associated molecular pattern ; ROS ; reactive oxygen species ; STING ; stimulator of interferon genes ; TFAM
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：223-230
- 全文大小：544 K
文摘
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Recent evidence highlights that mitochondrial DNA damage can directly promote atherosclerosis.
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Mitochondrial DNA damage leads to cell death, inflammation and altered metabolism.
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Mitochondrial dysfunction may not necessarily result in increased oxidative stress.
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Mitochondrial pathways may be the source of novel therapies for atherosclerosis.