Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats

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• 作者：Goiuri Alberdi ^{ggooiiuurrii@yahoo.es} ; Ví ; ctor M. Rodrí ; guez ^{bittor.rodriguez@ehu.es} ; Jonatan Miranda ^{jonatan.miranda@ehu.es} ; M. Teresa Macarulla ^{mariateresa.macarulla@ehu.es} ; Itziar Churruca ^{itziar.txurruka@ehu.es} ; Marí ; a P. Portillo ; ^{mariapuy.portillo@ehu.es}
• 关键词：Skeletal muscle ; Brown adipose tissue ; Mitochondria ; Thermogenesis ; Uncoupling proteins
• 刊名：Food Chemistry
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：141
• 期：2
• 页码：1530-1535
• 全文大小：739 K

文摘

The effect of resveratrol on thermogenesis in skeletal muscle and interscapular brown adipose tissue (IBAT) was investigated. Rats were fed an obesogenic diet supplemented with resveratrol (30 mg/kg/day) or not supplemented for 6 weeks. Resveratrol intake led to increased gene expression of mitochondrial-transcription-factor-A (TFAM), mitochondrial-protein-cytochrome-C-oxidase subunit-2 (COX2), sirtuin-1 (SIRT1), peroxisome-proliferator-activated-receptor-¦Â/¦Ä (PPAR¦Â/¦Ä) and proliferator-activated-receptor-gamma-coactivator1-¦Á (PGC-1¦Á) in IBAT and increased UCP1protein expression; however, peroxisome-proliferator-activated-receptor-¦Á (PPAR¦Á) expression remained unchanged. In gastrocnemius muscle, resveratrol increased the gene expression of TFAM and COX2; however, no changes were observed in levels of SIRT1, PGC-1¦Á and PPAR¦Â/¦Ä. Acetylated-PGC-1¦Á was decreased in the resveratrol-treated group, indicating a higher level of activation, and a significant increase of UCP3 protein expression was observed in this group. The increases in UCP protein expression in two important thermogenic tissues after resveratrol treatment may contribute to increased whole-body energy dissipation, which may help to better understand the body-fat lowering effect of this polyphenol.