MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice
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- 作者：Rui Zhanga ; b ; Huimin Zhoub ; c ; Lei Jianga ; Yueran Maoc ; Ximing Cuia ; Bing Xiea ; b ; Dongsheng Cuia ; Hui Wangd ; Qingfu Zhangb ; Shunjiang Xua ; b ; sjxu66@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease (AD) ; MicroRNA ; SAM mice ; Mitofusin 2 (mfn2) ; Hippocampus ; miR-195
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1652
- 期：Complete
- 页码：135-143
- 全文大小：1852 K
文摘
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mfn2 was downregulated with aging in the hippocampal tissue of SAMP8 mice.
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miR-195 directly targeted the 3′- UTR of mfn2 mRNA.
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miR-195 reduced the MMP by affecting the expression of mfn2.