Mitochondrial translation factors reflect coordination between organelles and cytoplasmic translation via mTOR signaling: Implication in disease
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- 作者：Xintao Caoa ; b ; Yan Qina ; b ; qiny@ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondrial translation ; Mitochondrial elongation factor 4 (mtEF4) ; mTOR ; Mitochondrial diseases
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：231-237
- 全文大小：1058 K
文摘
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mtEF4 is an elongation factor regulating tRNA translocation in mitoribosome.
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Activators, mitomiRs and MITRAC are direct regulators of mt-translation machinery.
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Mitochondrial and cytoplasmic translations are coordinated via mTOR signaling.
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Mitochondrial translation (regulatory) factors defects induce various human diseases.