A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly

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• 作者：Ana Stankovic¹ ; Lucie Y. Guo² ; Joã ; o F. Mata¹ ; Dani L. Bodor¹ ; ⁵ ; Xing-Jun Cao² ; Aaron O. Bailey³ ; ⁶ ; Jeffrey Shabanowitz⁴ ; Donald F. Hunt⁴ ; Benjamin A. Garcia² ; Ben E. Black² ; ^{blackbe@mail.med.upenn.edu} ; Lars E.T. Jansen¹ ; ⁷ ; ^{ljansen@igc.gulbenkian.pt}
• 关键词：centromere ; histone variant ; CENP-A ; mitosis ; epigenetics ; chromatin ; cyclin dependent kinase ; cell cycle ; kinetochore
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：231-246
• 全文大小：5321 K
• 卷排序：65

文摘

The HJURP conserved domain interacts with cyclin A Timing of M18BP1 localization is controlled by T653 phosphorylation Control of HJURP and M18BP1 suffices to cell-cycle restrict CENP-A assembly CENP-A assembly results in functional removal of M18BP1 from centromeres