The rat Pig-a assay using an erythroid HIS49 antibody in a single dose study of isopropyl p-toluenesulfonate

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• 作者：Satsuki Chikura ; ^{s.chikura@teijin.co.jp} ; Yuki Okada ; Takafumi Kimoto ; Hideshi Kaneko ; Daishiro Miura ; Yoshinori Kasahara
• 关键词：Pig-a assay ; Gene mutation ; IPTS ; Flow cytometry
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：811
• 期：Complete
• 页码：110-116
• 全文大小：800 K
• 卷排序：811

文摘

The Pig-a assay detected in vivo mutagenicity of IPTS in a single dosing study. The PIGRET assay showed increases in Pig-a MF earlier than the RBC Pig-a assay. The PIGRET assay is can detect a subtle increase in Pig-a MF induced by IPTS.