Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice
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- 作者：Paula Mosińskaa ; Katarzyna Socałab ; Dorota Nieoczymb ; Moshe Laudonc ; Martin Storrd ; e ; Jakub Fichnaa ; Piotr Wlaźb ; piotr.wlaz@umcs.lublin.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; serotonin ; ANOVA ; analysis of variance ; CC50 ; convulsive current inducing seizure response in 50% of mice ; CNS ; central nervous system ; DMSO ; dimethyl sulfoxide ; GABA ; γ-aminobutyric acid ; GI ; gastrointestinal ; i.p. ; intraperitoneally ; i.v. ; intravenously ; mCPP ; m-chlorophenylpiperazine ; MEST ; maximal electroshock seizure threshold ; MLT ; melatonin ; MT ; melatonin receptor ; N ; newtons ; NMDA ; N-methyl-D-aspartic acid ; NO ; nitric oxide ; PTZ ; pentylenetetrazole ; SEM ; standard error of the mean
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：307
- 期：Complete
- 页码：199-207
- 全文大小：1854 K
文摘
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Neu-P11 and Neu-P67 have a prolonged duration of action and oral availability, compared to MLT.
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MLT produced potent anticonvulsant effect in 6 Hz, MEST and PTZ tests.
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In contrast, neither Neu-P11 nor Neu-P67 affected the seizure threshold in 6 Hz, MEST and PTZ tests.
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Changes observed in the locomotor activity suggest the interaction of Neu-P11 and Neu-P67 in the CNS that is independent of MT.
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Effects of MLT have yet to be explored; our studies support its potential as an anticonvulsant therapeutic.