Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC

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• 作者：Christine Bassila^a ; ^{christine.bassila@univ-lorraine.fr} ; Rose Ghemrawi^a ; ^{rose.ghemrawi@univ-lorraine.fr} ; Justine Flayac^a ; ^{justine.flayac@univ-lorraine.fr} ; D. Sean Froese^b ; ^c ; ^{sean.froese@kispi.uzh.ch} ; Matthias R. Baumgartner^b ; ^c ; ^{matthias.baumgartner@kispi.uzh.ch} ; Jean-Louis Gué ; ant^a ; ^{jean-louis.gueant@univ-lorraine.fr} ; David Coelho^a ; ^{david.coelho@univ-lorraine.fr}
• 关键词：Rare disease ; Vitamin B12 ; Methionine synthase ; Methionine synthase reductase ; MMACHC ; MMADHC
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：103-112
• 全文大小：1377 K
• 卷排序：1863

文摘

MTR and MTRR interact with MMACHC and with MMADHC. These four proteins probably form a multiprotein complex. An impaired interactome could explain the reduced MTR activity in cblC defect.