刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1252-1258
全文大小:1307 K
卷排序:482
文摘
Mutations in mitochondrial peptidase, IMMP2L are associated with Tourette syndrome. The downstream effects of IMMP2L dysfunction in the human brain remain unclear. IMMP2L transcription requires Topoisomerase I in human primary astrocytes. IMMP2L knockdown leads to dysregulation of genes involved in central nervous system development. The transcriptional response to IMMP2L KD partially overlaps mitochondrial complex III inhibition.