Morphine administration induces change in anxiety-related behavior via Wnt/β-catenin signaling

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• 作者：Jiancai Wang<sup>1sup> ; Gang Zhu<sup>1sup> ; Lu Huang ; Tiejian Nie ; Kai Tao ; Yuqian Li ; Guodong Gao<sup> ; sup><sup>gguodong@outlook.comsup>
• 关键词：FZD ; frizzled family of wnt receptor ; BSA ; bovine serum albumin ; DMEM ; dulbecco&rsquo ; s modificationof eagle&rsquo ; s medium ; EPM ; elevated plus maze test
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：199-206
• 全文大小：2397 K
• 卷排序：639

文摘

Treatment with a low dose of morphine activates Wnt signaling. Morphine-exposed rats exhibited less cautious behavior, which was restored by treatment with DKK1. The decrease of dendritic spines after up-regulation of Wnt signaling caused by morphine treatment may have a role in cautious behavior change.