B cell-independent contribution of BAFF to murine autoimmune disease
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- 作者：William Stohl ; stohl@usc.edu" class="auth_mail" title="E-mail the corresponding author ; Agnes Banfalvi
- 关键词：AUC ; area under the curve ; B6 ; C57BL/6 ; BTg ; BAFF-transgenic ; EAE ; experimental autoimmune encephalomyelitis ; MOG35&ndash ; 55 ; myelin oligodendrocyte glycoprotein peptide 35&ndash ; 55 ; SOC ; standard-of-care ; SLE ; systemic lupus erythematosus ; Tg ; transgenic ; WT ; wild-type
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：172
- 期：Complete
- 页码：111-116
- 全文大小：579 K
文摘
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In MOG35–55-induced EAE, neutralization/elimination of BAFF has no effect on disease.
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Elimination of APRIL or constitutive over-expression of BAFF also has no effect.
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Eliminating BAFF has no effect in mice that maintain increased numbers of B cells.
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Eliminating BAFF in B cell-deficient mice dramatically reduces disease.
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This documents B cell-independent contribution of BAFF to an autoimmune disease.
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