Solvent-free synthesis of penta-substituted pyrroles: one-pot reaction of amine, alkyl acetoacetate, and fumaryl chloride

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• 作者：Abdolali Alizadeh ; Mohadese Babaki ; Nasrin Zohreh
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：21 February 2009
• 年：2009
• 卷：65
• 期：8
• 页码：1704-1707
• 全文大小：184 K

文摘

A novel, convenient, and efficient approach to the synthesis of penta-substituted pyrroles has been reported based on the multicomponent reaction. Solvent-free condition for the formation of enaminones from primary amines and alkyl acetoacetates and it's reaction with fumaryl chloride lead to the formation of pyrroles that have halide, CH₂CO₂H, ester functional groups, and two alkyl substitutions.