Shaken not stirred: A facile synthesis of 1,4-bis(furo[2,3-d]-pyrimidine-2,4(1H,3H)-dione-5-yl)benzenes by one-pot reaction of isocyanides, N,N′-dimethylbarbituric acid, and terephthaldialdehyde

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• 作者：Mohammad Bagher Teimouri and Reihaneh Bazhrang
• 关键词：Furopyrimidine ; Isocyanide ; Multicomponent reaction ; N ; N′ ; -Dimethylbarbituric acid ; Terephthaldialdehyde
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 July 2006
• 年：2006
• 卷：16
• 期：14
• 页码：3697-3701
• 全文大小：153 K

文摘

A simple and efficient synthesis of 1,4-bis(furo[2,3-d]pyrimidine-2,4(1H,3H)-dione-5-yl)benzene derivatives was achieved via a one-pot three-component reaction of isocyanides, N,N′-dimethylbarbituric acid, and terephthaldialdehyde in DMF at room temperature for 30 min. These improved reaction conditions allow the preparation of highly substituted furopyrimidinones in high yields and purity under mild reaction conditions.