Toll like receptor-2 regulates production of glial-derived neurotrophic factors in murine intestinal smooth muscle cells
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- 作者：Paola Bruna ; paola.brun.1@unipd.it" class="auth_mail" title="E-mail the corresponding author ; Serena Gobboa ; Valentina Caputib ; Lisa Spagnola ; Giulia Schiratoa ; Matteo Pasqualina ; Elia Levoratoa ; Giorgio Palù ; a ; Maria Cecilia Gironb ; Ignazio Castagliuoloa
- 关键词：Bdnf ; Brain Derived Neurotrophic Factor ; CM ; Complete Medium ; Cntf ; Ciliary Neurotrophic Factor ; EGCs ; Enteric Glial Cells ; ENS ; Enteric Nervous System ; FLA ; Flagellin ; FSL-1 ; Pam2CGDPKHPKSF ; GDNF ; Glial-Derived Neurotrophic Factor ; Lif ; Leukemia Inhibitory Factor ; LMMP ; Longitudinal Muscle Myenteric Plexus ; LPS ; Lipopolysaccharide ; M桅/DCs ; Macrophages/Dendritic Cells ; NGF ; Nerve Growth Factor ; Ntf ; Neurotrophin ; Pam3-CSK4 ; Pam3CysSerLys4 ; PAMPs ; Pathogen Associated Molecular Patterns ; Poly(I ; C)
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：68
- 期：Complete
- 页码：24-35
- 全文大小：1833 K
文摘
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Intestinal smooth muscle cells express TLR1-9 and neurotrophin mRNAs.
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TLR agonists stimulate specific neurotrophins in smooth muscle cells.
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Co-culture with smooth muscle cells corrects anomalies in neurons of TLR2−/− mice.
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Smooth muscle cells ensure neuronal integrity by GDNF production.