Sensitive determination of amlodipine besylate using bare/unmodified and DNA-modified screen-printed electrodes in tablets and biological fluids
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- 作者：Mohamed Khairya ; mohamed.khairy@science.sohag.edu.eg" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Ahmed A. Khorshedb ; Farouk A. Rashwana ; Gamal A. Salahc ; Hanaa M. Abdel-Wadoodc ; Craig E. Banksd ; c.banks@mmu.ac.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Amlodipine ; ct-DNA ; Screen-printed electrode ; Hypertension ; Molecular wires
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：239
- 期：Complete
- 页码：768-775
- 全文大小：1716 K
文摘
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Determination of amlodipine (AML) using bare/unmodified and DNA-modified graphite screen-printed electrodes (SPE) was explored.
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Although, bare SPE shows enhanced voltammetric oxidation peak of AML, the immobilization of DNA increases the sensitivity about 10-times higher than bare SPE.
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The detection limit was found to be 20.70 nM and 14.94 nM for unmodified and DNA-modified SPE.
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The unmodified SPE was for determination of AML in tablet and urine samples.