Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease
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- 作者：Manale Bensaida ; Patrick P. Michela ; Stewart D. Clarkb ; Etienne C. Hirscha ; Chantal Franç ; oisa ; Chantal.francois@upmc.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ChAT ; choline acetyl transferase ; DA ; dopaminergic ; Dtx-UII ; diphtheria toxin coupled to urotensin II ; Iba-1 ; ionized calcium-binding adaptor molecule 1 ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; NADPH ; nicotinamide adenine dinucleotide phosphate diaphorase ; NeuN ; neuronal nuclear protein ; PD ; Parkinson's disease ; PPN ; pedunculopontine nucleus ; SNc ; substantia nigra pars compacta ; TH ; tyrosine hydroxylase ; 6-OHDA ; 6-hydroxydopamine
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：275
- 期：part_P1
- 页码：209-219
- 全文大小：2035 K
文摘
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We used lesion paradigms in normal and parkinsonian rats and monkeys.
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Lesion of cholinergic pedunculopontine neurons affects dopaminergic neurons.
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Dopaminergic lesion results in losses of cholinergic pedunculopontine neurons.
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Double cholinergic and dopaminergic lesions aggravate neuronal losses.
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Strong reciprocal interactions exist between dopaminergic and cholinergic systems.