Anti-Parkinson effects of a selective alpha2C-adrenoceptor antagonist in the MPTP marmoset model
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- 作者：Ingrid H.C.H.M. Philippensa ; philippens@bprc.nl" class="auth_mail ; ingrid.philippens@gmail.com" class="auth_mail ; Marloes J.A. Joosenb ; Abdellah Ahnaouc ; Ignacio Andresd ; Wilhelmus (Pim) H.I.M. Drinkenburgc
- 关键词：ANOVA ; analysis of variance ; CNS ; central nerve system ; DA ; dopamine ; DA-ergic ; dopaminergic ; GPi ; globus pallidus interna ; LC ; locus coeruleus ; l-DOPA ; l-dihydroxy-phenylalanine ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; NE ; noradrenergic ; PPN ; pedunculopontine nucleus ; SNR ; substantia nigra reticula ; UPDRS ; Unified Parkinson's Disease Rating Scale
- 刊名：Behavioural Brain Research
- 出版年：1 August 2014
- 年：2014
- 卷：269
- 期：Complete
- 页码：81-86
- 全文大小：727 K
文摘
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Indirect targeting dopaminergic neurotransmission may provide innovative therapeutic potential in Parkinson's disease.
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The alpha2C-adrenoceptor antagonist JNJ27063699 mitigates motor deterioration in MPTP monkey model of Parkinson's disease.
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The anti-parkinsonian therapeutic dose of JNJ27063699 is devoid from side effects.
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Adrenergic intervention may be successful to improve motor control in Parkinson's disease.