Inhibition of HCN channel activity in the thalamus attenuates chronic pain in rats
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- 作者：Weihua Dinga ; b ; c ; 1 ; Zerong Youa ; 1 ; Shiqian Shena ; Lucy Chena ; Shengmei Zhub ; smzhu20088@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianren Mao ; Dr.a ; jmao@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCN channel ; ZD7288 ; Thalamus ; Neuropathic pain ; Monoarthritis
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：19 September 2016
- 年：2016
- 卷：631
- 期：Complete
- 页码：97-103
- 全文大小：2192 K
文摘
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Inhibition of HCN channel activity in the VPL nucleus of the thalamus attenuated chronic pain.
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HCN1 and HCN2 protein expression levels were increased in the thalamus under chronic pain condition.
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Increased HCN channel activity in the thalamus contributed to the maintenance of chronic pain.