Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine

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• 作者：Sté ; phanie Gré ; goire^a ; ^b ; ¹ ; ^{stephanie.gregoire.sg@gmail.com" class="auth_mail} ; Anne-Sophie Wattiez^a ; ^b ; ^{as.wattiez@gmail.com" class="auth_mail} ; Monique Etienne^a ; ^b ; ^{monique.etienne@udamail.fr" class="auth_mail} ; Fabien Marchand^a ; ^b ; ^{fabien.marchand@udamail.fr" class="auth_mail} ; Denis Ardid^a ; ^b ; ^{denis.ardid@udamail.fr" class="auth_mail}
• 关键词：Chronic inflammatory pain ; Emotion ; Cognition ; Amygdala ; Morphine ; Rats
• 刊名：European Journal of Pharmacology
• 出版年：15 July 2014
• 年：2014
• 卷：735
• 期：Complete
• 页码：1-9
• 全文大小：1060 K

文摘

Chronic pain is a multidimensional experience that not only includes changes in nociception but also impairments in emotional and cognitive functions, not often taken into account in preclinical research. The present study investigated emotional and cognitive impairments in an animal model of persistent inflammatory pain as well as the involvement of the basolateral complex (BLC) of the amygdala in these components. Monoarthritis was induced by intra-articular injection of complete Freund壮s adjuvant. Mechanical hypersensitivity, anxiety and depressive-like behaviours as well as cognitive capacities were assessed using several tests, such as von Frey, social interaction, open field, saccharin preference, spatial and social recognition memory tests. The effects of morphine administered systemically or into the BLC of the amygdala were also studied. Monoarthritic rats exhibited mechanical hypersensitivity, anxiety and depressive-like behaviours as well as cognitive impairments. Whereas low systemic doses and intra-BLC infusion of morphine failed to reduce mechanical hypersensitivity, they reversed monoarthritis-induced anxiety-like behaviours and cognitive impairments. Our findings further support a crucial role of amygdala in the effect of morphine on emotional/cognitive components of pain and not on mechanical hypersensitivity. Finally, our study highlights the interest of a multi-behavioural approach in the assessment of pain and the analgesic effect of drugs.