Combination of neutralizing monoclonal antibodies against Hepatitis C virus E2 protein effectively blocks virus infection
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- 作者：Mihika Bosea ; Ranajoy Mullickb ; Soma Dasa ; Saumitra Dasb ; Anjali A. Karandea ; anjali@biochem.iisc.ernet.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：ELISA ; enzyme-linked immunosorbent assay ; EDTA ; ethylenediaminetetra-acetic acid ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HCV ; hepatitis C virus ; HCV-LPs ; hepatitis C virus-like particles ; mAbs ; monoclonal antibodies ; PBS ; phosphate buffered saline ; PCR ; polymerase chain reaction ; VLPs ; virus-like particles ; FBS ; foetal bovine serum
- 刊名：Virus Research
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：224
- 期：Complete
- 页码：46-57
- 全文大小：3553 K
文摘
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Generation of mAbs against the genotype 3a of HCV (prevalent in India).
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Neutralizing mAbs significantly inhibit virus binding and entry to hepatoma cells.
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Epitopes recognised by the mAbs are unique, distinct and non-overlapping.
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Combination of the mAbs significantly prevent viral (JFH1 strain) infection ex vivo.