Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria

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• 作者：J.C. Whitney¹ ; ² ; P.L. Howell¹ ; ² ; ^{howell@sickkids.ca}
• 关键词：synthase ; exopolysaccharide ; alginate ; cellulose ; poly-¦Â-d-N-acetylglucosamine
• 刊名：Trends in Microbiology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：21
• 期：2
• 页码：63-72
• 全文大小：1126 K

文摘

The biosynthesis and export of bacterial cell-surface polysaccharides is known to occur through several distinct mechanisms. Recent advances in the biochemistry and structural biology of several proteins in synthase-dependent polysaccharide secretion systems have identified key conserved components of this pathway in Gram-negative bacteria. These components include an inner-membrane-embedded polysaccharide synthase, a periplasmic tetratricopeptide repeat (TPR)-containing scaffold protein, and an outer-membrane ¦Â-barrel porin. There is also increasing evidence that many synthase-dependent systems are post-translationally regulated by the bacterial second messenger bis-(3¡ä-5¡ä)-cyclic dimeric guanosine monophosphate (c-di-GMP). Here, we compare these core proteins in the context of the alginate, cellulose, and poly-¦Â-d-N-acetylglucosamine (PNAG) secretion systems.