Riboswitches: From living biosensors to novel targets of antibiotics
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- 作者：Elnaz Mehdizadeh Aghdama ; b ; c ; mehdizadehe@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author ; aghdamelnaz@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammad Saeid Hejazia ; b ; Abolfazl Barzegard ; e
- 关键词：5&prime ; UTR ; 5&prime ; Untranslated region ; miRNA ; microRNAs ; siRNA ; small interfering RNA ; c-di-GMP ; cyclic di guanosine monophosphate ; c-di-AMP ; cyclic di adenosine monophosphate ; SD ; Shine&ndash ; Dalgarno ; MDR ; multiple drug resistance ; BLISS ; the Breaker Lab Intergenic Sequence Server ; PAGE ; Polyacrylamide Gel Electrophoresis ; CM ; Covariance Model ; glmS ; glucosamine-6-phosphate ; ZMP ; 5-Amino-4-imidazolecarboxamide riboside 5&prime ; -monophosphate ; GFP ; green fluorescent protein ; 2 ; 4 DNT ; 2 ; 4-di
- 刊名：Gene
- 出版年：2016
- 出版时间：5 November 2016
- 年：2016
- 卷：592
- 期：2
- 页码：244-259
- 全文大小：709 K
文摘
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Riboswitches are natural RNA biosensor for metabolites located in 5′UTR of mRNA.
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Riboswitch regulates genes by transcription/translation termination or mRNA degradation.
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Riboswitches are potential templates to design artificial RNA switches and biosensors.
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Riboswitches are interesting drug targets to design new antibiotics.
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