Different prognosis of acute myeloid leukemia harboring monosomal karyotype with total or partial monosomies determined by FISH: Retrospective PALG study

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• 作者：Ewa Wawrzyniak^a ; ^{ewa.wawrzyniak@umed.lodz.pl} ; Agnieszka Wierzbowska^a ; Aleksandra Kotkowska^b ; Monika Siemieniuk-Rys^b ; Tadeusz Robak^a ; Wanda Knopinska-Posluszny^c ; Agnieszka Klonowska^d ; Mariola Iliszko^d ; Renata Woroniecka^e ; Barbara Pienkowska-Grela^e ; Anna Ejduk^f ; Malgorzata Wach^g ; Ewa Duszenko^h ; Anna Jaskowiec^h ; Malgorzata Jakobczykⁱ ; Barbara Mucha^j ; Joanna Kosny^a ; Agnieszka Pluta^a ; Sebastian Grosicki^k ; Jerzy Holowiecki^l ; Olga Haus^h ; ^j
• 关键词：Monosomal karyotype ; Acute myeloid leukemia ; FISH ; Banding techniques ; Prognosis
• 刊名：Leukemia Research
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：37
• 期：3
• 页码：293-299
• 全文大小：614 K

文摘

A monosomal karyotype (MK) was identified by banding techniques (BT) in acute myeloid leukemia (AML). However, BT may be insufficient to determine the actual loss of a complete chromosome, especially in complex karyotypes. We have investigated the effect of monosomy type, total (MK-t) and partial (MK-p), reevaluated by FISH, on prognosis. We have found that complete remission rate and probability of overall survival at 1 year was higher in MK-p (n = 27) than MK-t (n = 15) group (40 % vs. 15.4 % , P = 0.19 and 30 % vs. 9 % , P = 0.046, respectively). Our results indicate for the first time that monosomy type influences the prognosis of MK-AML.